Development of Asymmetric Propargylic Substitution Reactions Using Transition Metal Catalysts

Bifunctional transition metal-based molecular catalysts for asymmetric syntheses.

The discovery and development of conceptually new chiral bifunctional transition metal-based catalysts for asymmetric reactions is described. The chiral bifunctional Ru catalyst was originally developed for asymmetric transfer hydrogenation of ketones and imines and is now successfully applicable to enantioselective C-C bond formation reaction with a wide scope and high practicability. The depr...

Transition Metal Sulfide Catalysts for Petroleum Upgrading – Hydrodesulfurization Reactions

Transition metal-catalyzed allylic substitution reactions with unactivated allylic substrates.

The transition metal-catalyzed allylic substitution of unactivated allylic substrates (allylic alcohols, allylic ethers and allylic amines) is rapidly becoming an important area of research. There are several advantages to using these substrates in allylic substitution reactions: the use of unactivated alcohols minimizes the production of waste by-products and reaction steps; and allylic ethers...

Transition‐Metal‐Free Borylation of Allylic and Propargylic Alcohols

The base-catalyzed allylic borylation of tertiary allylic alcohols allows the synthesis of 1,1-disubstituted allyl boronates, in moderate to high yield. The unexpected tandem performance of the Lewis acid-base adduct, [Hbase](+) [MeO-B2 pin2 ](-) favored the formation of 1,2,3-triborylated species from the tertiary allylic alcohols and 1-propargylic cyclohexanol at 90 °C.

Biomimetic oxidation in organic synthesis using transition metal catalysts

Simulation of the function of hepatic flavoenzyme and Cytochrome P-450 with transition metal-complex catalysts results in finding biomimetic, catalytic oxidations of amines, amides, alkenes, and hydrocarbons.